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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
Frontiers of Medicine doi: 10.1007/s11684-023-1044-4
Keywords: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
Keratin 5-Cre-driven deletion of
Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang
Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 305-317 doi: 10.1007/s11684-019-0722-8
Keywords: acne inversa mouse model interleukin 1 family member 6 small proline rich protein 2D key inflammatory
Jianping Ye
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z
Keywords: inflammation obesity cytokine energy expenditure insulin resistance
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 41-45 doi: 10.1007/s11684-007-0008-4
Keywords: Functional experiment anti-tumor dendritic clinical
He Yongfu
Strategic Study of CAE 2008, Volume 10, Issue 9, Pages 92-95
Keywords: ionic liquids microwave irradiation conductivity [BMIm]PF6 [PMIm]PF6 [C6MIm]PF6
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 714-728 doi: 10.1007/s11684-022-0959-5
Keywords: FRMD6 lung cancer mTOR pathway
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 217-226 doi: 10.1007/s11684-014-0326-2
This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC). A total of 1021 healthy controls, 302 HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCC patients) were enrolled in this study. Quantitative PCR was used to genotype rs3783553. HBV mutations were determined by direct sequencing. Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations, and their interactions with the risk of HCC. No significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAg seroclearance subjects, HBsAg-positive subjects without HCC, and all controls. Additionally, rs3783553 was not significantly associated with chronic HBV infection, liver cirrhosis, HBV e antigen seroconversion, abnormal alanine aminotransferase, and high viral load (>104 copies/ml). However, the TTCA insertion allele of rs3783553 was significantly associated with an increased frequency of HBV C7A mutation compared with homozygous TTCA deletion carriers [(del/ins+ ins/ins) vs. del/del, adjusted odds ratio (OR)=1.48, 95% confidence interval (CI)=1.09-2.02, P=0.013]. Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC in males, with an adjusted OR of 0.64 (95% CI=0.42-0.98; P=0.041) after age and HBV genotype were adjusted. Although rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant allele may predispose the host to selecting HBV C7A mutation during evolution and significantly reduce the risk of HCC caused by HBV preS deletion. This study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis and is helpful in determining HBsAg-positive subjects who are likely to develop HCC.
Keywords: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
RNA m6A modification and its function in diseases
Jiyu Tong, Richard A. Flavell, Hua-Bing Li
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNAmodification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m66A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1).However, the mechanism and the regulatory network of m6A are still largely unknown.
Keywords: RNA modification m6A immunity cancer epigenetics
Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO
Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang
Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2, Pages 340-350 doi: 10.1007/s11705-020-1942-9
Keywords: nano AgCl@BaSO4 co-precipitates antibacterial flame resistance PA6 composite PA6 yarn
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 458-475 doi: 10.1007/s11684-022-0968-4
Keywords: LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous
A rolling 6U parallel mechanism
Zhihuai MIAO, Yanan YAO
Frontiers of Mechanical Engineering 2011, Volume 6, Issue 1, Pages 96-98 doi: 10.1007/s11465-011-0214-2
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 482-491 doi: 10.1007/s11684-018-0633-0
Keywords: LGR6 colon adenocarcinoma immunohistochemistry prognosis
Single and joint effects of HHCB and cadmium on zebrafish (
Lei ZHANG, Jing AN, Qixing ZHOU
Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 3, Pages 360-372 doi: 10.1007/s11783-011-0353-z
Keywords: 1 3 4 6 7 8-hexahydro-4 6 6 7 8 8-hexamethylcyclopenta-gamma-2-benzopyran (HHCB) cadmium (Cd) antioxidant
Evolution and innovation of antenna systems for beyond 5G and 6G Editorial
Bao-yan DUAN
Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 1, Pages 1-3 doi: 10.1631/FITEE.2010000
Keywords: None
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12, Pages 1925-1936 doi: 10.1007/s11705-023-2344-6
Keywords: Cs2AgBiBr6 nanocrystals visible-light photocatalyst Cs2AgBiBr6/TiO2 heterojunction
Title Author Date Type Operation
Keratin 5-Cre-driven deletion of
Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang
Journal Article
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
Jianping Ye
Journal Article
murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
Journal Article
Synthesis of [RMIm]PF6(R=P, B, C6)ionic liquid under microwave irradiation and research of its conductivity
He Yongfu
Journal Article
FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression
Journal Article
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Journal Article
RNA m6A modification and its function in diseases
Jiyu Tong, Richard A. Flavell, Hua-Bing Li
Journal Article
Antibacterial and anti-flaming PA6 composite with metathetically prepared nano AgCl@BaSO
Wei Zhang, Boren Xu, Caihong Gong, Chunwang Yi, Shen Zhang
Journal Article
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors
Journal Article
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma
Wenjing Wang, Shigang Ding, Hejun Zhang, Jun Li, Jun Zhan, Hongquan Zhang
Journal Article
Single and joint effects of HHCB and cadmium on zebrafish (
Lei ZHANG, Jing AN, Qixing ZHOU
Journal Article